The problem and misconduct
These changes are associated with high risk for cardiovascular disease, diabetes and some types of cancer that could shorten your life or make it very unpleasant
This is a bad modern and their presence predates the diagnoses of diseases that produce.
The drugs do not cure the metabolic condition, but can be cured by modifying the weight and body fat/muscle composition. This is extremely important because we believe that metformin is abused offering unrealistic expectations and lowering in the second place, the most important aspect of the strategy: weight loss and a healthy routine of life in the long run!
We have seen many patients with dubious/inappropriate indications for metformin (Glucofage) which we mock crossly of who said it and handicapped us by patients that they used it or use it lightly.
Regardless of the results of laboratory, if a person has "metabolic" features must start immediately balanced diet, exercise and weight loss schemes. Drugs are secondary and often unnecessary.
Insulin resistance is the basis of glucosidic tolerance and diabetes disorders.
Normal: glycemia and insulin at normal values.
Without elevation of glycemia insulin resistance: high normal glycemia with insulin.
High blood sugar with insulin resistance: high levels of insulin-glucose high in the range of intolerance to carbohydrate or diabetes.
When insulin resistance is accompanied by some level of hyperglycemia should include these general measures and the use of appropriate drugs, including insulin.
The patient is unknown his presence although some seek help for overweight and difficult to lose body weight.
Criteria diagnoses, women (M), men (H), at least 2 required:
- Central obesity: Abdominal circumference greater than 80 cm (M), 90 cm (H)
- Hypertriglyceridemia: More than 150 mg/dL triglycerides
- HDL cholesterol: less than 50 mg/dL (M), 40 mg/dL (H)
- Hypertension: figures higher than 130 mmHg systolic or 85 mm Hg diastolic
- In fasting hyperglycemia: glucose greater than 100 mg/dL or type 2 diabetes
The coloration of the skin (Acanthosis nigricans) and Hyperandrogenism (HIRSUTISM, acne, lack of menstruation) can also be included as part of metabolic syndrome without being criteria for its diagnosis
Similarly, physical exercise and the correction of inadequate habits is the first and best way to available therapy.
Hyperandrogenism and insulin resistance are probably hereditary and share certain relationships that make them susceptible to improve synchronously by applying appropriate measures
Hyperinsulinemia control leads to decrease of Hyperandrogenism. Current evidence suggests that the basic problem of the SOP is the insulin resistance and androgenic hormone disorder: the use of hypoglycemic decreases the resistance, decreases Hyperandrogenism, helps restore ovulation and may improve the rate pregnancy in cases where you want a pregnancy making more efficient the ovulation.
Concepts and others
Abdominal central obesity measurement
You must take when you exhale. Go around your waist with the measuring tape at the level of the navel. Less than or equal to 80 cm in women, 90 cm or less in men.
Glycemia in fast
Measurement of sugar in blood or plasma after an approximate 8 hour fast.
Postprandial glycemia
Measurement of sugar in blood or plasma 2 hours after a usual meal for the person. This non-standard and measuring the patient's personal response to the food stimulus.
Tolerance glucosidic curves
Serial measurement of blood sugar levels after ingestion of a standardized amount of glucose.
Object: overloading the pancreatic function for detecting faults in extreme conditions
Currently favors the intake of 75 g of pure glucose (Glucola75, G75) measurements at 0 (fast) and 2nd hours after the intake of glucose without intermediate measurements of 30 minutes. 1st time measurement is still practiced in some laboratories.
Diagnostic for diabetes and glucosidic intolerance.
Serial measurements of glucose and insulin serum before (time 0, fast) and then (2nd time) 75 g of glucose intake.
Intolerance glucosidic
Glycemia in fasting between 100 – 125 mg/dL or equal to or less than 199 mg/dL glucose (140 – 199 mg/dL) in the curve of G75
HOMA
Index obtained with a single measurement of glucose and insulin in serum during fasting (sens 57%). If we add the measurement of triglyceride in best (sens 64%).
Diabetes
Glycemia in fasting more than 126 mg/dL or sugar levels equal to or greater than 200 mg/dL in the curve of G75, 2nd hour